Freedom Softgels® Inflammation Complex 60 Softgels

Directions: Adults: Take two (2) softgels once daily with a meal.

HTN Freedom Softgels^®

With an unprecedented number of clinically proven ingredients, our new Freedom Softgels^® are specially formulated to target chronic inflammation.  While it is true that inflammation is part of our body’s natural healing process, chronic inflammation can lead to several serious conditions.

A double-blind, placebo-controlled, randomized clinical trial, recently concluded at UCLA Medical Center, shows how Freedom Softgels® significantly reduced inflammatory markers in study subjects.  In just 30 days, researchers found a significant reduction in systolic blood pressure among those taking Freedom Softgels® as well as a significant reduction in high sensitivity C Reactive Protein and a reduced Interleukin-6 (both key markers of inflammation).  Also noted was a significant increase in the Omega-3 fatty acid index along with EPA levels and overall improved endothelial function in the Freedom Softgels® study group.[i]

Freedom Softgels^®, an innovative union of 7 ingredients clinically substantiated to combat inflammation yielding a truly revolutionary product!

Let’s take a closer look at the possible benefits provided by each ingredient – a high absorption Curcumin, wild caught Fish Oil, Gamma Linolenic Acid, a full-spectrum Vitamin E complex, Vitamin D, Hydroxytyrosol, and organic Astaxanthin: 

Curcumin (as Cavacurcumin^®): Curcumin is well known for its anti-inflammatory and anti-oxidant properties.  Several clinical studies have shown beneficial outcomes for a myriad of illnesses and health conditions,[ii]^,[iii],[iv] immune responses,[v] and cardiovascular health.[vi]  However, these amazing benefits tend to be hindered by curcumin’s limited absorption as it is not soluble in water.  Fortunately, in this specially formulated gamma-cyclodextrin complex, Cavacurcumin^® is able to greatly enhance the bioavailability of curcumin, increasing the amount of curcumin absorbed in the body by nearly 40 times!!  A clinical trial, published in The European Journal of Nutrition,[vii] shows just how the encapsulation of curcumin in this gamma-cyclodextrin formula is able to increase the solubility, dispersibility and overall absorption of curcumin in the body, enabling you to enjoy all the benefits of curcumin.  Each serving of Freedom Softgels^® contains 1000mg of this high absorption curcumin.

Fish Oil (as Epax^®): Fish oil continues to be recommended by medical professionals as research continues to substantiate beneficial outcomes with inflammatory control, strengthened cardiovascular systems and improved cognition.[viii]  The omega 3 fatty acids contained within fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are converted by our bodies into powerful anti-inflammatory agents called resolvins, which help to protect from the pro-inflammatory cytokines and prostaglandins.  Numerous clinical studies have shown a positive correlation between fish oil supplementation and improved inflammation control in those suffering from chronic inflammatory conditions.[ix]^,[x]   In fact, several studies have shown omega 3 fatty acids to be as effective as NSAIDs (nonsteroidal anti-inflammatory drugs) without the side effects.[xi] 

EPA and DHA, have also been shown to maintain a normal heart rhythm, preventing dangerous erratic rhythms, or arrhythmias, which are the leading cause of cardiac-related deaths.  These fatty acids are beneficial in maintaining healthy blood pressure and blood vessel function, as well as promoting healthy lipid profiles, thus the risk of developing arterial plaques.[xii]  In fact, one study found a reduced risk of sudden cardiac death by nearly 50% for those subjects who took just 1g of omega 3 daily.[xiii]  Fish oil is also important for optimal cognitive health as EPA and DHA are abundant in brain cell membranes, helping to enhance intercellular communication and maintain overall cell membrane health.[xiv]  These fatty acids play an important role in brain development and function throughout all stages of life; several studies have highlighted that importance on the brains of developing children, showing a strong correlation between fish oil intake and a higher intelligence,[xv]^{, [xvi]} and in older adults an inadequate intake of omega 3s has been found to decrease the risks of developing amyloid plaques[xvii] while supplementation with DHA was shown beneficial for memory and overall cognition.[xviii]  Fish oil has also been found to improve mental health by lessening depressive symptoms.[xix]^{, [xx]} 

Epax^®fish oil is procured from wild caught, South Pacific fish in an eco-friendly manner; Epax^®is Friends of the Sea certified for sustainability as well as Halal certified.  Utilizing molecular distillation, a specially developed process for heat sensitive elements - such as omega 3 fatty acids - Epax^® is able to protect the structure of the omega 3s and deliver the highest purity fish oil available.

Each serving of Freedom Softgels^® contains a total of 850mg of Epax^® fish oil, which has 80% of the omega 3s in their natural triglyceride form, 450mg EPA, and 100mg DHA, plus 125mg of an additional omega 3 complex.  

Astaxanthin (as AstaZine^®): Astaxanthin, a powerful antioxidant, is also a potent anti-inflammatory agent, which has been shown in numerous clinical studies to reduce inflammation markers in the body, such as C-reactive protein (CRP).[xxi]^{, [xxii]}  This protein, CRP, is produced by the liver in response to inflammation and can be measured with a simple blood test; a CRP level above 350mg/L is indicative of a serious underlying condition, such as joint stiffening, digestive complications, infection, or other injury, resulting in systemic inflammation[xxiii].  An elevated CRP can also be an indication of impending heart disease[xxiv].  A lowered CRP level not only prevents muscle and joint damage from inflammation, thus decreasing pain associated with arthritic conditions, but it also supports a healthy cardiovascular system, promoting improved blood flow, lower lipid levels and reduced risk of atherosclerosis.  Thankfully, our bodies do not need to combat the cursers of inflammation on their own, as we can turn to astaxanthin for the assist.  One clinical trial showed a 20% reduction in CRP levels among study subjects who took just 4mg of natural astaxanthin daily compared to the placebo group![xxv] 

Freedom Softgels^® contain 6mg Astazine^® astaxanthin per serving.  Astazine^® is the first, and only, organic astaxanthin on the market, and is sustainably cultivated from the micro-algae Haematococcus pluvialisis utilizing the sun’s energy combined with pristine Himalayan water.  Not only is Astazine^® morally manufactured with the highest quality and standards in mind, it is clinically validated by independent research to promote a normal inflammatory response, healthy cardiovascular system, healthy immune function, and support eye, brain and joint health.

Hydroxytyrosol (as HTEssence^®):  The main phenolic component of olive oil, hydroxytyrosol is one of the most powerful antioxidants around, with an ORAC (Oxygen Radical Absorbance Capacity) of over 68,500, but is also a strong anti-inflammatory reducing key markers of inflammation, such as CRP.[xxvi]  Olive oil, a prominent part of the Mediterranean diet, is well known for its heart healthy properties, and hydroxytyrosol is one of the reasons why; numerous clinical studies have shown hydroxytyrosol to reduce LDL cholesterol and reduce the risk of developing plaques that obstruct blood flow to the brain and heart, thus having a therapeutic effect on the overall cardiovascular system.[xxvii]^,[xxviii]  Each serving of Freedom Softgels^® contains 12.5mg of HTEssence^®, which is a high-absorbency, pure hydroxytyrosol that has been nano-encapsulated and clinically vetted to provide cardio-protective and anti-inflammatory benefits.

Vitamin E (as Evnol^® Mixed Tocotrienols):  Evnol^® is a full spectrum Vitamin E complex containing all 8 natural forms of Vitamin E (4 tocopherols and 4 tocotrienols) to maximize the benefit.  Those benefits go beyond healthy skin and hair; as powerful antioxidants, tocotrienols protect cells from damaging free radicals, but can also increase insulin sensitivity,[xxix] helping to regulate blood sugar, improve cholesterol levels, and lower the risk of developing heart conditions[xxx]^{, [xxxi]} while also having a neuroprotective effect[xxxii].  Tocotrienols also help combat inflammation,[xxxiii]^,[xxxiv] reducing CRP, cytokines and other inflammatory indicators.[xxxv]   Modern research shows the importance of a full spectrum Vitamin E, as is seen in nature, and that is precisely why Freedom Softgels^® contains 25mg of this mixed tocotrienol complex per serving. 

Gamma-Linolenic Acid (as Sonova^®-400): Gamma-Linolenic Acid (or GLA) is an important Omega-6 fatty acid beneficial in regulating inflammatory mediators, such as prostaglandins and eicosanoids,[xxxvi] and lipid metabolism[xxxvii].  Clinical trials have also highlighted GLA as beneficial in those suffering from joint inflammation, with a 36% reduction in joint tenderness found in one such study.[xxxviii]  Our bodies convert linoleic acid into GLA, however age, diet and lifestyle factors often inhibit adequate production, making GLA one of the most frequently deficient fatty acids[xxxix] and signaling supplementation may be warranted.  Sonova^®, the GLA present in Freedom Softgels^®, is derived from safflower seed oil with a high concentration of bioavailable GLA.

Vitamin D3 (as cholecalciferol): Well known for its contribution towards maintaining strong bones and immune health, research has also shown inflammatory benefits with Vitamin D supplementation.  A study published in the Journal of Immunology highlights how vitamin D suppresses the production of specific proteins known to cause inflammation, such as cytokines, leading researchers to conclude that those suffering from chronic inflammatory disease may benefit from increasing their vitamin D intake.[xl]   Each serving of Freedom Softgels^® contain 2,000 IUs of pure cholecalciferol (vitamin D3) to help you meet your needs.

As with all of our Health Thru Nutrition products, Freedom Softgels^® is manufactured in a cGMP certified facility in the USA.  It is hypoallergenic, being free of milk or milk by-products, egg or egg by-products, shellfish or shellfish by-products, tree nut, peanut or peanut by-products, wheat or wheat by-products; it is Gluten Free and non-GMO.

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[i] Budoff, M. (2019). Final Study Report of the 30-day placebo controlled study of Freedom Softgels, a proprietary formula containing vitamin D3, turmeric extract, omega 3 rich fish oil, GLA tacotrienols, hydroxytyrosol and astaxanthin.  UCLA Medical Center - LA Biomedical Research Institute. Report submitted for publication.

[ii] Asher GN, Spelman K (2013) Clinical utility of curcumin extract. Altern Ther Health Med 19(2):20–22

[iii] Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G (2007) Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem 282(22):15954–15964.

[iv] Chandran B, Goel A (2012) A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res PTR 26(11):1719–1725.

[v] Jagetia GC, Aggarwal BB (2007) “Spicing up” of the immune system by curcumin. J Clin Immunol 27(1):19–35.

[vi] DiSilvestro RA, Joseph E, Zhao S, Bomser J (2012) Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J 11:79.

[vii] Purpura, M., Lowery, R.P., Wilson, J.M. et al. Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects. Eur J Nutr (2018) 57: 929.

[viii] Swanson D, Block R, Mousa SA. Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life. Advances in Nutrition. 2012;3(1):1-7.

[ix] Proudman SM, Cleland LG, James MJ. Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utility. Rheum Dis Clin North Am. 2008 May;34(2):469-79.

[x] Lee YH, Bae SC, Song GG. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Arch Med Res. 2012 Jul;43(5):356-62.

[xi] Maroon, JC, Bost, JW. Omega-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain.  World Neurosurgery, 2006 Apr;65(4):326-31.

[xii] Leaf A. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. J Cardiovasc Med. (Hagerstown). 2007; 8 Suppl 1:S27-29.

[xiii]  Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico. Lancet. 1999; 354:447-55.

[xiv] Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Frontiers in Aging Neuroscience. 2015;7:52.

[xv] Oken E, Wright RO, Kleinman KP, et al. Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort. Environmental Health Perspectives. 2005;113(10):1376-1380.

[xvi] Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics. 2003.  Jan;111(1):e39-44.

[xvii] Tan ZS, Harris WS, Beiser AS, et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012;78(9):658-664.

[xviii] Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M; MIDAS Investigators. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010, Nov;6(6):456-64.

[xix] Mocking RJT, Harmsen I, Assies J, Koeter MWJ, Ruhé HG, Schene AH. Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Translational Psychiatry. 2016;6(3):e756.

[xx] Grosso G, Galvano F, Marventano S, et al. Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms. Oxidative Medicine and Cellular Longevity. 2014;2014:313570.

[xxi] Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutrition & Metabolism. 2010;7:18.

[xxii] Kidd P. Astaxanthan, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Alterm Med Review. 2011; 12:16(4): 355-64.

[xxiii] Landry A, Docherty P, Ouellette S, Cartier LJ. Causes and outcomes of markedly elevated C-reactive protein levels. Canadian Family Physician. 2017;63(6): e316-e323.

[xxiv] Fonseca FAH, de Oliveira Izar MC. High-Sensitivity C-Reactive Protein and Cardiovascular Disease Across Countries and Ethnicities. Clinics. 2016;71(4):235-242. 

[xxv] Spiller G, Dewell A, Chaves S, Rakidzich Z. Effect of daily use natural astaxanthin on C-reactive protein.  Health Research and Studies Center, Los Altos, CA. 2006;1:31.

[xxvi] Sanchez-Fidalgo S, et al. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. Eur J Nutr. 2012 Jun;51(4):497-506.

[xxvii] Gonzalez-Santiago M, et al. One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development.  Atherosclerosis. 2006 Sep;188(1):35-42.

[xxviii] Vazquez-Velasco M, et al. Effects of hydroxytyrosol-enriched sunflower oil consumption on CVD risk factors. Br J Nutr. 2011 May;105(10):1448-52.

[xxix] Fang F, Kang Z, Wong C. Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors. Mol Nutr Food Res. 2010 Mar;54(3):345-52.

[xxx] Meganathan P, Fu JY. Biological Properties of Tocotrienols: Evidence in Human Studies. Int J Mol Sci. 2016;17(11):1682.

[xxxi] Das S, Mukherjee S, Lekli I, et al. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan;360(1-2):35-45

[xxxii] Sen CK, Khanna S, Roy S.  Tocotrienol: the natural vitamin E to defend the nervous system?  Ann NY Acad Sci.  2004 Dec; 1031:127-42.

[xxxiii] Wong WY, Poudyal H, Ward LC, Brown L. Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats. Nutrients. 2012 Oct;4(10):1527-41.

[xxxiv] Yam ML, et al. Tocotrienols suppress proinflammatory markers and cyclooxygenase-2 expression in RAW264.7 macrophages. Lipids, 2009.  44(9): 787-97.

[xxxv] Prasad K. Tocotrienols and cardiovascular health. Curr Pharm Des. 2011;17(21):2147-54.

[xxxvi] Johnson MM, et al. Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans.  J Nutr. 1997;127(8):1435-44.

[xxxvii] Chilton FH, et al. Mechanism by which botanical lipids affect inflammatory disorders.  Am J Clin Nutr. 2008; 87(2):498S-503S. 

[xxxviii] Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med; 1993; 119(9):867–73.

[xxxix] Dobryniewsky J, et al. The gamma-linolenic acid (GLA)—the therapeutic value. Przegl Lek. 2007;64(2):100-02.

[xl] Yong Z, et al. Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1. J Immunol. 2012; 188(5):2127-2135.

Other Ingredients: Gamma Cyclodextrin, kosher beef gelatin, medium chain triglycerides, vegetable glycerin, purified water, maltodextrin, palm olein, curcuma oil, ascorbyl palmitate, annatto suspension in sunflower oil, turmeric suspension in sunflower oil, d-alpha tocopherol, plant squalene, natural lemon oil, natural mixed tocopherols, sterol complex, sunflower oil, mixed carotenoid complex and organic extra virgin olive oil. Highly refined fish oil from anchovy, sardine, and mackerel.

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